A Review Of cafergot discontinued
A Review Of cafergot discontinued
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Keep track of Closely (1)pirtobrutinib will raise the stage or result of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
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apalutamide will lower the extent or effect of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicines which have been CYP3A4 substrates may end up in reduce publicity to these prescription drugs.
aprepitant will improve the amount or effect of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
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caffeine will decrease the extent or effect of iobenguane I 131 by Other (see remark). Stay clear of or Use Alternate Drug. Dependant on the mechanism of motion of iobenguane, prescription drugs that lower catecholamine uptake or that deplete catecholamine stores could interfere with iobenguane uptake into cells, and so, lessen iobenguane efficacy.
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lumefantrine will minimize the level or result of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
C: Use with caution if Gains outweigh dangers. Animal studies demonstrate risk and human studies not readily available or neither animal nor human experiments completed.
itraconazole will boost the amount or influence of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Greater threat of ergotism resulting in cerebral ischemia and/or ischemia in the extremities
Small (one)rifampin will lessen the level or outcome of caffeine by impacting hepatic enzyme CYP1A2 metabolism.
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Monitor Closely (one)palbociclib will increase the level or impact of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. The dose of delicate CYP3A substrates that has a slim therapeutic index could need to be reduced if coadministered with palbociclib